The Ultimate Fighting Championship (UFC), the premier organization in mixed martial arts (MMA), has seen many changes over the years in its rules and regulations. One of the most controversial periods in the sport’s history was when fighters were allowed to use Testosterone Replacement Therapy (TRT) exemptions. This era, spanning the late 2000s to early 2014, is remembered for the debates it sparked about fairness, safety, and the integrity of the sport. What is TRT? Testosterone Replacement Therapy is a medical treatment intended for men who have abnormally low levels of testosterone, a condition known as hypogonadism. TRT involves supplementing the body’s testosterone through injections, gels, or patches to restore normal levels, helping alleviate symptoms such as fatigue, depression, and decreased libido. TRT in MMA: The Rationale and Controversy In MMA, the use of TRT began to gain attention as fighters claimed it was necessary for their health and well-being. Proponent