Testosterone Replacement Therapy (TRT) has been a topic of considerable research interest, especially concerning its safety and efficacy. Here, we delve into some of the most notable studies from the past year, highlighting their findings and implications. Cardiovascular Safety: The TRAVERSE Trial One of the most comprehensive studies on TRT to date is the TRAVERSE trial, led by the Cleveland Clinic. This randomized, placebo-controlled study enrolled 5,246 men aged 45 to 80 who had hypogonadism and were at high cardiovascular risk or had preexisting cardiovascular disease. The participants were divided to receive either daily 1.62% testosterone gel or a placebo. Key Findings: Cardiovascular Events : Over a mean duration of 22 months, TRT did not significantly increase the incidence of major adverse cardiovascular events compared to placebo. Specifically, 7.0% of the testosterone group experienced such events versus 7.3% in the placebo group​ ( newsroom.clevelandclinic ) ​​